Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis.

Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis.

Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. The monoclonal antibody MF1, which mediates clearance of peripheral microfilaremia in a gerbil infection model, recognizes two stage-specific proteins, p70 and p75, in B. malayi microfilariae. cDNA coding for the MF1 antigen was sequenced, and the predicted protein sequence shows significant similarities to chitin...

Brugian Filariasis in Japan

A tiny islet named Hachijo-Koshima was known as the only one focus of brugian filariasis in Japan. It is located about 300 km south to Tokyo in the Pacific Ocean. It had been rather hard to access due to the lack of the regular transportation system. The island was visited for the first time after the last World War II by the medical doctors for the investigation of the nature of a debilitating...

Identification of 38kDa Brugia malayi microfilarial protease as a vaccine candidate for lymphatic filariasis.

A FPLC purified 38kDa protease (Bm mf S-7) isolated from B. malayi microfilarial soluble antigen was identified. It showed pronounced reactivity with sera collected from 'putatively immune' asymptomatic and amicrofilaraemic individuals residing in an endemic area for bancroftian filariasis. Further the immune protective activity of Bm mf S-7 antigen was evaluated in susceptible hosts, jirds (Me...

Lymphatic Filariasis in Thailand A Review on Distribution and Transmission

Introduction As early as 1919, MENDELSON (20) mentioned in his paper on "Tropical diseases observed in Siam" fever and elephantiasis in connection with microfilaraemia in Thailand. The disease causing filariae, however, were not further specified. Over 30 years later IYENGAR (17) conducted a survey on human filariasis in four southern provinces on the peninsula of Thailand. Of a total of 4,112 ...

Lymphatic Filariasis Transmission and Control: A Mathematical Modelling Approach